基于类风湿关节炎患者“风湿瘀阻，筋伤骨损”的病机特点，提出“祛风除湿，通利血脉，畅通经络，健脾补肾， 强筋壮骨”的治法，简称“祛湿通脉法”。在“祛湿通脉法”治疗原则的指导下，可根据正邪虚实，选用经验方如昆断益母 方、南续益母颗粒、三藤舒筋方以及经方如桂枝芍药知母汤、黄芪桂枝五物汤、半夏泻心汤等进行随症加减的中药治疗， 并可配合膏方、外治法、功能锻炼等，从而构建具有中医药优势的类风湿关节炎防治体系。该课题组所开展的系列临床和实验 研究结果表明，“祛湿通脉法”治疗类风湿关节炎具有增效减毒的作用，是发挥中医药优势以防治类风湿关节炎的理论创新。

The recurrence of psoriasis has always been a difficult problem in the treatment of psoriasis，and with the widely use of biological agents，this problem will become more prominent in the future. The pathogenesis of psoriasis is characterized by deficiency in the origin and excess in the superficiality，manifesting that spleen-kidney yang deficiency is the root cause of psoriasis，triggered external pathogens is the predisposing factor of psoriasis，and blood-heat and stasis obstruction becomes the secondary symptoms of psoriasis. In this article，it is proposed that psoriasis is a kind of diseases of internal injury in nature，and the recurrence of psoriasis is closely related to the pathogenesis of‘blood-heat and stasis obstruction as the secondary symptoms，and spleen-kidney deficiency as the root cause’. The recurrence is due to the fact that the treatment only suppresses the secondary symptoms of blood heat but fails to eliminate the root cause of depletion and deficiency. Therefore，the therapy of consolidating vital base should be performed throughout the treatment of psoriasis，and the methods of eliminating dampness and removing stasis should be adopted depending on the presence of water-dampness retention and blood stasis stagnation so as to achieve the overall stable therapeutic effect.

R259.322

国家自然科学基金资助项目 （编号：81173634，81774262，81573930，82174301）