银屑病复发一直是银屑病治疗中的难点，且随着生物制剂的广泛应用，这一问题未来会更突出。该课题组从银屑病的“脾肾阳虚是其根本，外邪触发是其诱因，血热瘀滞是其标象”的“本虚标实”病机观出发，提出银屑病的本质是一类内伤性疾病，银屑病的反复发作与其“以血热瘀阻为标，以脾肾亏虚为本”的病机特点密切相关；复发是因治疗手段仅抑制了“血热”之标象，而未能修复亏虚之本。故在银屑病的治疗中，固本之法应当贯穿始终，并结合其水湿停留、瘀血结滞之标实，重视祛湿与化瘀，方能取得更加稳定的整体疗效。

The recurrence of psoriasis has always been a difficult problem in the treatment of psoriasis，and with the widely use of biological agents，this problem will become more prominent in the future. The pathogenesis of psoriasis is characterized by deficiency in the origin and excess in the superficiality，manifesting that spleen-kidney yang deficiency is the root cause of psoriasis，triggered external pathogens is the predisposing factor of psoriasis，and blood-heat and stasis obstruction becomes the secondary symptoms of psoriasis. In this article，it is proposed that psoriasis is a kind of diseases of internal injury in nature，and the recurrence of psoriasis is closely related to the pathogenesis of‘blood-heat and stasis obstruction as the secondary symptoms，and spleen-kidney deficiency as the root cause’. The recurrence is due to the fact that the treatment only suppresses the secondary symptoms of blood heat but fails to eliminate the root cause of depletion and deficiency. Therefore，the therapy of consolidating vital base should be performed throughout the treatment of psoriasis，and the methods of eliminating dampness and removing stasis should be adopted depending on the presence of water-dampness retention and blood stasis stagnation so as to achieve the overall stable therapeutic effect.

R275.9

国家自然科学基金集成项目 （编号：U23A6012）；国家自然科学基金重点支持项目 （编号：U20A20397）；国家中医药管理局中医药创新团队及人才支持计划项目 （编号：ZYYCXTD-C-202204）