“脾主运化，脾气散精”是脾藏象理论的核心内容。中焦脾土可运化水谷并转输精微，维护机体糖脂代谢稳态，“脾主运化，脾气散精”与糖脂代谢在生理功能上具有一致性。脾虚则纳运失职，易感外邪；气虚血滞而内生湿热，久积不通则化瘀为毒，导致“炎-癌”转化，“脾虚为本，瘀毒互结”与“炎-癌”转化在病理改变上具有相关性。健脾散精化浊可改善糖脂代谢紊乱，健脾化瘀解毒可遏制胃的“炎-癌”转化进程。从机体糖脂代谢角度探索“脾主运化，脾气散精”功能本质的科学内涵，聚焦消化系统重大疾病的“炎-癌”转化进程并探讨消化道炎症性疾病、癌前病变等的证候演变规律及其“从脾论治”的药效机制，将丰富脾藏象理论的科学内涵，助力中医药的现代化和国际化，已成为当前脾胃研究领域的新方向。

The core of theory of visceral manifestation of spleen is about‘spleen in charge of transportation and transformation，spleen qi dispersing the essence’. Middle-jiao spleen-earth has the functions of digesting food and transporting food essence，and maintaining the homeostasis of glucose and lipid metabolism in the body.‘Spleen in charge of transportation and transformation，spleen qi dispersing the essence’functions like the glucose and lipid metabolism at physiological state. The deficiency of spleen results in the dysfunction of food in-take and digestion and the susceptibility to external pathogens；qi deficiency and blood stasis lead to the interior damp-heat，and the long-term accumulation of damp-heat develops into stasis and then turns into toxins，which eventually induces inflammation-to-tumor transition. The pathogenesis of‘spleen deficiency being the root cause and stasis blended with toxins’is correlated with the pathological changes of inflammation-to-tumor transition. The therapy of strengthening the spleen，dispersing essence and removing turbidity is effective on improving the disorder of glucose and lipid metabolism，and the therapy of strengthening the spleen，resolving stasis and removing toxin is effective on restraining the process of inflammation-to-tumor transition in the stomach. It has become a new direction in the field of spleen-stomach research to expound the scientific connotation of the essence of spleen function of‘spleen in charge of transportation and transformation，spleen qi dispersing the essence’from the perspective of glucose and lipid metabolism，to focus on the inflammation-to-tumor transition process of major diseases of digestive system，to explore the evolution of the traditional Chinese medicine syndromes of inflammatory diseases and precancerous lesions of the digestive tract，and to reveal the pharmacological mechanism of treatment from the perspective of spleen，which will enrich the scientific connotation of theory of visceral manifestation of spleen and promote the modernization and internationalization of traditional Chinese medicine.

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国家自然科学基金资助项目 （编号：82174319，82305169，T2341009）；广东省重大专项 （编号：2020B1111100011）；国家中医药传承创新团队资助项目 （编号：ZYYCXTD-C-202208）；广东省中医药局重点研究项目 （编号：20215005）