肺癌是我国发病率和死亡率均居第一位的肿瘤。该研究团队在国医大师周岱翰教授指导下，根据近40年的肺癌诊疗经验，认为“痰”为肺癌发病的关键，并结合肺癌的临证特点，进一步提出“痰毒”致病的理论。肺癌为本虚标实之病，肺脾气虚为“痰毒”产生的关键，“痰毒”为肺癌发生发展的关键病机因素，据此凝练出益气除痰的肺癌治疗大法。该研究团队近年来的临床实践表明，益气除痰法治疗中晚期肺癌尤其是老年中晚期肺癌疗效确切，可延长中晚期肺癌患者的生存期、改善肺癌患者的生活质量及肺癌相关症状、增效减毒抗肿瘤治疗、防治早期肺癌等；益气除痰方的抗肿瘤机制与抑制肺癌的转移、调控细胞周期、抑制上皮间质转化、调控细胞凋亡与自噬、改善表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKIs）耐药性等有关。

Lung cancer has the highest morbidity and mortality in China.Guiding by Chinese medical master ZHOU Dai-Han and based on the experience of diagnosis and treatment of lung cancer in the past 40 years，the authors believe that phlegm is the key to the pathogenesis of lung cancer，and then put forward the phlegm-toxin pathogenesis theory according to the clinical characteristics of lung cancer. Lung cancer is a disease of deficiency in origin and excess in superficiality.Qi deficiency of lung and spleen leads to the formation of phlegm-toxin，and phlegm-toxin is the key pathogenic factor for the development and progression of lung cancer. Based on the phlegm-toxin pathogenesis，the treatment of lung cancer with the method of replenishing qi and removing phlegm（abbreviated as Yiqi Chutan method）is proposed. The clinical practice of the research team in recent years has shown that Yiqi Chutan method is effective in the treatment of middle-to-advanced lung cancer，in particular the middle-to-advanced lung cancer in the elderly，which can prolong the survival time of patients with advanced lung cancer，improve the quality of life of lung cancer patients，relieve lung cancer related symptoms，enhance the efficacy and reduce the toxicity of anti-tumor treatment，and prevent and treat early lung cancer.The study on the anti-tumor mechanism of Yiqi Chutan method showed that the anti-tumor mechanism of Yiqi Chutan Formula was related to the inhibition metastasis of lung cancer，regulation of cell cycle，inhibition of epithelial-mesenchymal transition regulation of the apoptosis and autophagy of cells and improvement of the EGFR-TKIs resistance.

R273.42

国家科技部重点研发计划项目 （编号：2022YFC3500203）；广东省基础与应用基础研究基金项目 （编号：2022B1515230003）；广州市科学技术局重点研发计划项目 （编号：SL2022B01J10007）；广州市科学技术局基础研究计划项目 （编号：2023A03J0300）