探讨“伏邪理论”对新冠病毒感染等所致疫病的病机认识、防治思路的指导意义。“伏气”为温病病因，亦为人身阳热之气；阳热之气郁伏于内可成为伏热体质，伏热体质与温病的发生发展尤为密切，伏热体质更易致温邪为患。伏邪理论对中医防治新冠病毒感染所致疫病的启示主要为：气候反常是疫病发生的重要预警和外在条件；同气相求，伏邪与新感病邪性质相关，易内伤太阴，脾虚湿聚则成“伏湿”；从伏邪理论防治疫病，有助于辨识证候重点，制定针对病机的核心治法，截断病情。基于伏邪理论，针对伏湿的祛湿法为新冠病毒感染预防和早期治疗的重要治法。该课题组以燥湿、化湿、利湿、健脾等多种祛湿法组方，拟定了预防新冠病毒感染的中药方“五指防冠方”（由五指毛桃、薏苡仁、茯苓、火炭母、苍术、广藿香、甘草组成），该方可应用于新冠病毒感染的预防和早期治疗。祛湿法的疗效机制主要与改善机体的免疫紊乱状态、恢复机体抗病能力有关。

This article discussed the significance of latent pathogen theory in the understanding of pathogenesis and prevention and treatment of epidemic diseases such as novel coronavirus infection（COVID-19）. Latent-qi is the cause of epidemic febrile disease，and it is also the yang-heat qi of human body. The stagnant yang-heat qi hidden in the body can induce the latent heat constitution. The latent heat constitution is particularly closely related to the development and progression of epidemic febrile disease，and is susceptible to the warm pathogen. The significance of the latent pathogen theory on the prevention and treatment of epidemic diseases such as COVID-19 with traditional Chinese medicine is as follows：abnormal climate is an important early warning and is the external condition for the development of epidemic diseases；latent pathogen is easily assimilated into the newly-attacked pathogenic factors for the assimilation of similar nature，and then injuries taiyin-spleen，which causes spleen deficiency and dampness accumulation and then results in latent dampness；preventing and treating epidemic diseases based on the latent pathogen theory is helpful for identifying the key syndromes，formulating the core regimen indicated for the pathogenesis，and cutting off the progression of the disease. Based on the latent pathogen theory，dampness-removing therapy for latent dampness is important for the prevention and early treatment of COVID-19，and our research group has developed a Chinese herbal formula of Wuzhi Fangguan Prescription（composed of Fici Simplicissimae Radix，Coicis Semen，Poria，Herba Polygoni Chinensis，Atractylodis Rhizoma，Pogostemonis Herba，and Glycyrrhizae Radix et Rhizoma）to prevent COVID-19 early by using a variety of dampness-removing methods such as drying dampness，resolving dampness，draining dampness，and invigorating spleen.The prescription is indicated for the prevention and early treatment of COVID-19.The mechanism of dampness-removing therapy is mainly related to the improvement of the disordered immune function and restoration of the body’s resistance to diseases.

R259.631

国家自然科学基金资助项目 （编号：81903957）；广东省中医药局项目 （编号：2020ZYYJ06）；第四批广东省名中医传承工作室项目 （粤中医办函[2023]108号）