【目的】采用数据挖掘方法探讨溃疡性结肠炎 （ulcerative colitis，UC） 缓解期的中医用药规律，为临床遣方用药提供参 考。【方法】检索 2000年7月至2022年12月发表在中国知网 （CNKI） 、万方 （Wanfang Data） 、维普中文期刊数据库 （VIP） 中有 关中药治疗溃疡性结肠炎缓解期患者的临床研究或医案类文献。运用Excel 2019对纳入文献的处方药物进行频数统计、性味 归经分析，采用Modeler 18.0和SPSS Statistics 26.0进行关联规则分析、聚类分析，并用Cytoscape 3.9.1构建药物的关联网络 图。 【结果】共纳入文献121篇，提取得到药物167味，其中高频药物为24味，主要包括白术、茯苓、木香、黄连、党参、白 芍、薏苡仁 、黄芪、炙甘草 、当归 、陈皮 、山药等。药物功效分类以补虚药、清热药、理气药、利水渗湿药、止血药、 解表药、温里药、收涩药、化湿药、活血化瘀药为主；药性以温、平、寒为主，五味偏甘、苦、辛，用药大多归脾、胃、 肺、肝经。挖掘得到25个药物关联规则，聚类分析得到5个组方。 【结论】中药治疗溃疡性结肠炎缓解期的组方多由参苓白 术散、四神丸、痛泻要方等经典方加减而成，药物配伍体现了从脾论治的治疗思想，健脾除湿、行气调血并重，后期注重 补火助阳，多药相合，多法并用以标本兼治。

Objective To investigate the medication rules of tradition Chinese medicine for the treatment of ulcerative colitis （UC） at remission stage by data mining method，thus to provide reference for clinical prescription and medication. Methods The clinical research or medical case report of UC remission treated by Chinese medicine issued in CNKI，Wanfang Data and VIP from July 2000 to December 2022 were retrieved. Excel 2019 was used to analyze the frequency statistics，and the distribution of the nature，flavor and meridian tropism of the prescribed drugs in the included literature. Modeler 18.0 and SPSS Statistics 26.0 were used for association rules and cluster analysis，and Cytoscape 3.9.1 was used to construct the network diagram of the associated drugs. Results A total of 121 articles were included in the analysis，involving 167 drugs，of which 24 drugs were frequently used，mainly including Atractylodis Macrocephalae Rhizoma， Poria， Aucklandiae Radix， Coptidis Rhizoma， Codonopsis Radix，Paeoniae Radix Alba，Coicis Semen，Astragali Radix，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，Angelicae Sinensis Radix，Citri Reticulatae Pericarpium，and Dioscoreae Rhizoma. According to the therapeutic actions，the drugs were mainly classified into deficiency-supplementing drugs，heat-clearing drugs， qi-regulating drugs，urination-promoting and dampness-percolating drugs，blood-stanching drugs，exterior- relieving drugs，interior-warming drugs，astringent drugs，dampness-resolving drugs，and blood-activating and stasis-resolving drugs. The medicinals were mainly warm，mild and cold in nature，and were sweet，bitter and pungent in flavor. Most of the drugs had the meridian tropism of the spleen，stomach，lung and liver. A total of 25 drug association rules were mined out，and five prescriptions were obtained after cluster analysis. Conclusion The Chinese medicine prescriptions for the treatment of UC remission usually deprive from the classical formulas such as Shenling Baizhu San，Sishen Pills，and Tongxie Yaofang. The compatibility of drugs reflects the thoughts of treating UC remission from the perspective of spleen，and embodies the therapies of strengthening the spleen and removing dampness， promoting qi and regulating blood， and focusing on tonifying ministerial fire and supporting yang in the later stage， which has the characteristics of treating both symptoms and root causes simultaneously by using multiple drugs through multiple methods.

R259.746.2

国家自然科学基金面上项目 （编号：82174126）；广东省中医药局科研项目 （编号：2021168）；广州市科技计划项目 （编号： 202201020377）；教育部高等中西医结合类专业教学指导委员会2022年度教育研究课题 （编号：2022-ZC11）；2022年广州中医 药大学校级教学质量与教学改革工程项目；新黄埔中医药联合创新研究院项目 （编号：2022IR017）