【目的】探讨癫痫患儿的出生日期、胎孕期干支运气分布规律及与癫痫罹患的相关性。 【方法】采用病例对照研究，收 集就诊于天津中医药大学第一附属医院儿科门诊的癫痫患儿共1 113例 （病例组） 以及同时期就诊的非癫痫患儿2 346例 （对照 组） ，采用χ2 检验、二元Logistic回归等对患儿胎孕及出生时的运气禀赋进行统计分析。 【结果】（1） 出生日期运气分布研究： 病例组与对照组在出生时主气分布上差异有统计学意义 （P＜0.05） ，初之气最多[215 （19.30%） ]，终之气最少[145 （13.0%） ]。 在出生时岁运、主运、客运、客气、司天在泉之气分布上差异无统计学意义 （P＞0.05） 。二元Logistic回归分析结果提示，出 生于壬年（OR=1.444，95%CI：1.055-1.975）、初之气（OR=1.363，95%CI：1.057-1.757）、五之气（OR=1.378，95%CI： 1.065-1.783） 后天发生癫痫的风险增加。 （2） 胎孕期运气分布研究：病例组与对照组在胎孕期岁运、司天在泉之气分布上差异 无统计学意义 （P＞0.05） 。二元Logistic回归分析结果提示，胎孕期岁运为太木-太木 （OR=1.866，95%CI：1.142-3.048） 、少 阳相火司天厥阴风木在泉 （OR=1.672，95%CI：1.004-2.786） 后天发生癫痫的风险增加。 【结论】先天运气禀赋与小儿癫痫的发 生有一定相关性。

Objective To investigate the correlation of the distribution patterns of stem-branch circuit qi at birth and at conception of children with the predisposition to pediatric epilepsy. Methods A case-control study was conducted in 1 113 children with epilepsy （case group） and 2 346 non-epilepsy children （control group） who sought medical consultation in the Pediatric Outpatient Department of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine at the same period. Chi-square test and binary logistic regression were used to analyze the circuit qi endowment of children between the two groups at conception and at birth. Results （1） The analysis of the circuit qi distribution at birth showed that there was a statistically significant difference in the distribution of dominant qi between the case group and the control group at birth （P＜0.05） . The initial qi （the first circuit qi in the theory of six climatic factors） accounted for the most （215 cases，19.30%） and the sixth qi accounted for the least （145 cases，13.0%） . There was no significant difference in the distribution of suiyun （yearly evolutive phase），dominant circuit（regular yearly evolutive phase），guest circuit（alterable yearly evolutive phase） ，guest qi （alterable yearly circuit qi） and sitian （the first half of the alterable yearly circuit qi） at birth （P＞ 0.05） . The results of binary logistic regression analysis showed that the risk of predisposition to epilepsy in the children was increased when the children were born in the Chinese lunar year of Ren （OR = 1.444，95%CI： 1.055-1.975） ，at the initial qi （OR = 1.363，95%CI：1.057-1.757） and at the fifth qi （OR = 1.378，95%CI：1.065-1.783） . （2） The analysis on the distribution of circuit qi at conception showed that there was no significant difference in the distribution of suiyun and sitian-zaiquan semiannual circuit qi between the case group and the control group （P＞0.05） . Binary logistic regression analysis showed that the risk of predisposition to epilepsy in the children was increased when pregnancy in the suiyun of taimu-taimu （OR=1.866，95%CI ：1.142-3.048） and at sitian semiannual circuit qi of shaoyang minister fire and zaiquan semiannual circuit qi of jueyin wind-wood （OR = 1.672，95%CI：1.004-2.786） . Conclusion There is a certain correlation between circuit qi endowment and the prevalence of pediatric epilepsy.

R272.6

国家自然科学基金面上项目 （编号：82174434）；第五批全国中医临床优秀人才研修项目 （国中医药办人教函[2021]271号）