【目的】 对近10年来国内五苓散应用研究的相关文献进行可视化分析，探讨五苓散的应用情况。【方法】 检索中国知网 （CNKI）中 2013 年 1 月 1 日至 2022 年 12 月 31 日五苓散应用研究的学术期刊文献，通过 CiteSpace 软件绘制相应的知识图谱， 并对文献的关键词进行可视化分析。【结果】 检索获得 1 121篇五苓散应用研究相关文献，经筛选后纳入 1 104篇进行可视化 分析。关键词共现分析结果显示，五苓散可用于治疗肝硬化腹水、慢性心力衰竭、糖尿病肾病等多系统疾病，且多与桃红 四物汤、真武汤、小柴胡汤、肾气丸、苓桂术甘汤配伍应用，主要针对的症状有水肿、小便不利、尿潴留等；常用的研究 方法有网络药理学、分子对接等。关键词突现分析结果显示，五苓散应用研究的热点表现为2013年的“肝硬化”、2015年的 “茵陈蒿汤”、2018年的“脑水肿”、2020年开始的“网络药理学”“新型冠状病毒肺炎”“心功能”。【结论】 五苓散临床应用 广泛，偏重于治疗水液代谢障碍的疾病，五苓散治疗肝硬化腹水、慢性心力衰竭及糖尿病肾病为近年来的研究热点。五苓 散应用于新型冠状病毒肺炎、改善心功能方面的研究为当前研究的趋势与关注点。

Objective A visualized analysis of the relevant literature on the application of Wuling San（FiveIngredient Powder Containing Poria）in China in the recent 10 years was conducted to explore the application of Wuling San. Methods The applied research of Wuling San issued in the academic journals of CNKI from January 1， 2013 to December 31， 2022 were retrieved. The corresponding knowledge graphs were drawn with CiteSpace software，and the keywords of the literature were visualized and analyzed. Results A total of 1 121 articles related to the applied research of Wuling San were obtained after preliminary retrieval，and 1 104 articles were included for visual analysis after screening. The results of keyword co-occurrence analysis showed that Wuling San was usually used for treating cirrhosis ascites， chronic heart failure， diabetic nephropathy and other multi-system diseases， and it was mostly used by the compatibility of Taohong Siwu Decoction， Zhenwu Decoction， Xiaochaihu Decoction，Shenqi Pills and Linggui Zhugan Decoction. Wuling San was indicated for the symptoms of edema， dysuria and urinary retention. The commonly-used research methods for Wuling San included network pharmacology，molecular docking，etc. The results of keyword burst analysis showed that the hotspots of Wuling San applied research were as follows：cirrhosis in 2013，Yinchenhao Decoction in 2015，cerebral edema in 2018， and network pharmacology，novel coronavirus-infected pneumonia and cardiac function since 2020. Conclusion Wuling San is widely used in the clinic， and is indicated for water metabolism disorders. Wuling San in the treatment of cirrhotic ascites， chronic heart failure and diabetic nephropathy becomes the research hotspots in recent years. The applied researches of Wuling San on novel coronavirus-infected pneumonia and on improving cardiac function have become the trend and focus of current research.

R289.5

国家自然科学基金面上项目（编号：82174284）