形气神三位一体生命观是古人对人体生命的基本认知。卵巢早衰（premature ovarian failure，POF）是卵巢功能丧失的终 末阶段，是困扰当代育龄期妇女生活、生育的一大难题。中医认为，人是形、气、神三位一体的有机整体，形、气、神三 者中的任何一者发生异常都可能直接导致疾病的发生并影响另二者的功能。该文从肾精亏虚及脾失健运导致形体失常、少 阳枢机不利而致气机失调、肝气郁结而致神机失守3个方面来认识卵巢早衰性不孕的发病机制，并基于恢复形气神三位一体 正常态的治疗思想，采用补肾健脾以补形、运转枢机以理气、疏肝养血以安神之法指导卵巢早衰性不孕的中医治疗。基于 “形气神三位一体生命观”论治卵巢早衰性不孕，可深化对卵巢早衰不孕的病因病机认识，充分发挥中医调经种子的优势。

The life view of physique-qi-spirit trinity is our ancestors’basic understanding of human life. Premature ovarian failure（POF）is the end stage of ovarian function loss，and it is a major problem that plagues the life and fertility of contemporary women of childbearing age. In the view of traditional Chinese medicine（TCM）， human beings are an organic unity of the trinity of physique，qi and spirit. The disorders of any of the physique，qi and spirit may directly lead to the occurrence of diseases and affect the function of the other two. In this paper，the pathogenesis of infertility associated with POF is discussed from three aspects based on the view of physique-qispirit trinity： kidney essence deficiency and spleen dysfunction leading to abnormal physique， inactivation of shaoyang pivot leading to disordered qi movement，and liver qi stagnation leading to mental derangement. Aimed to restore the normal state of the physique-qi-spirit trinity，the TCM treatment of infertility associated with POF can be achieved by the methods of tonifying the kidney and strengthening the spleen to supplement the physique， activating the pivot to regulate qi，soothing the liver and nourishing the blood to calm the mind. Discussion on the treatment of infertility associated with POF from the perspective of the life view of physique-qi-spirit trinity will deepen the understanding of the etiology and pathogenesis of infertility associated with POF，and will embody the advantages of TCM for regulating menstruation and promoting gestation.

R271.14

广东省中医药局科研项目（编号：20212203）；深圳市科技创新科研项目（编号：2021-255）；福田区卫生公益性科研项目（编号： FTWS2021008）