【目的】采用数据挖掘方法分析国家专利中药复方治疗糖尿病周围神经病变 （diabetic peripheral neuropathy，DPN） 的用 药规律，为临床用药提供参考。 【方法】在国家知识产权局网站检索中药复方治疗DPN的专利，使用Excel 2021进行频数统 计，运用RAW Graphs 2.0制作高频中药功效的桑基图，运用SPSS Statistics 25.0软件进行药物的系统聚类分析，基于 Cytoscape 3.9.1挖掘核心处方。 【结果】共纳入101首中药专利复方，涉及243味中药。出现频次居前3位的中药为丹参、黄 芪、白芍。治疗DPN的专利复方药物的药性以温、平为主，药味以甘、苦、辛为主，归经以归肝、心、脾经居多。药物按 功效主要可分为补虚药、活血化瘀药、解表药、平肝熄风药、清热药、止血药、安神药、利水渗湿药。关联规则分析中支 持度最高的药物组合为黄芪-当归；系统聚类分析将出现频次居前31位的中药分成7组，挖掘得到的核心处方包含黄芪、川 芎、鸡血藤、丹参、牛膝、桂枝、当归共7味药。 【结论】专利中药复方治疗DPN以补虚、活血化瘀为主，兼以温通经络，重 视后天之本，健脾更不忘疏肝；临证时可选用黄芪-当归及白芍-丹参药对；核心方 （黄芪、川芎、鸡血藤、丹参、牛膝、桂 枝、当归） 可加减用于DPN的全病程治疗。

Objective To analyze the medication rules of national patented Chinese herbal compounds for the treatment of diabetic peripheral neuropathy（DPN） by data mining method，and to provide reference for clinical medication. Methods The patents of Chinese medicine compound for the treatment of DPN were retrieved from the website of the China National Intellectual Property Administration （CNIPA） . Excel 2021 was used for frequency statistics. RAW Graphs 2.0 was used to make a Sankey diagram of the efficacy of high-frequency Chinese medicinals. SPSS Statistics 25.0 software was used for hierarchical cluster analysis of the medicines，and the core prescriptions were mined based on Cytoscape 3.9.1. Results A total of 101 patented prescription were included， involving 243 herbs. The top three Chinese medicines in the descending order of occurrence frequency were Salviae Miltiorrhizae Radix et Rhizoma，Astragali Radix，and Paeoniae Radix Alba. Most of the medicines of patented Chinese medicine compounds for the treatment of DPN were warm and mild in nature，sweet，bitter and pungent in flavor，and had the meridian tropism of liver，heart and spleen meridians. According to the therapeutic actions， the medicine can be divided into tonic drugs，blood-activating and stasis-removing drugs，exterior-releasing drugs， liver-calming and wind-extinguishing drugs， heat-clearing drugs， bleeding-arresting drugs， mind- calming drugs，and urination-promoting and dampness-percolating drugs. The association rule analysis revealed the drug combination of Astragali Radix and Angelicae Sinensis Radix with the highest support. After hierarchical cluster analysis，the top 31 Chinese medicinals were classified into 7 groups. The core prescription which was composed of 7 medicines， namely Astragali Radix， Chuanxiong Rhizoma， Spatholobi Caulis， Salviae Miltiorrhizae Radix et Rhizoma，Achyranthis Bidentatae Radix，Cinnamomi Ramulus and Angelicae Sinensis Radix was finally mined out. Conclusion The treatment of DPN with patented Chinese herbal compounds is based on the therapies of supplementing deficiency，activating blood and removing stasis，and warming and unblocking meridians and collaterals. Meanwhile，consolidating the acquired foundation by strengthening spleen and soothing liver is also stressed. Clinically，the herbal pairs of Astragali Radix-Angelicae Sinensis Radix，Paeoniae Radix Alba-Salviae Miltiorrhizae Radix et Rhizoma are the optional drugs， and the core prescription composed of Astragali Radix，Chuanxiong Rhizoma，Spatholobi Caulis，Salviae Miltiorrhizae Radix et Rhizoma，Achyranthis Bidentatae Radix，Cinnamomi Ramulus and Angelicae Sinensis Radix can be used for the whole course of DPN.

R255.4；R587.2

国家重点研发计划项目 （编号：2019YFC1709301）；范冠杰广东省名中医传承工作室项目 （粤中医办函[2020]1号）；广东省中医 院名中医药专家学术经验传承工作室项目 （编号：Y0054.E54101）