【目的】基于数据挖掘技术探讨岭南罗氏妇科当代传承人辨治绝经前后诸证的思路与用药规律。 【方法】收集岭南罗氏 妇科当代传承人门诊治疗绝经前后诸证的医案，采用古今医案云平台 （V2.3.5） 对病案数据进行频数统计、关联规则分析、聚 类分析及复杂网络分析。 【结果】最终纳入医案191份，处方191首，涉及中药160味。四诊信息及证型统计显示，绝经前后 诸证的病机以本虚为主，正虚失调，枢机不利，多脏受累，其中肝肾阴虚证最为常见。出现频次 ≥ 40次的高频中药有26味， 居前5位的中药为百合、党参、山茱萸、白芍、熟地黄。药物的性味以甘平为主，多入肝、心、肾、脾经。关联规则分析共 获得15对高置信度药物组合；高频中药的聚类分析得到5类核心药物组合。复杂网络分析揭示了以熟地黄、山茱萸、菟丝 子、百合、酸枣仁、丹参、珍珠母为主的核心处方。关联规则分析得到使用频次较高的药对为女贞子-山茱萸及女贞子-丹 参。 【结论】岭南罗氏妇科当代传承人治疗绝经前后诸证以滋养肝肾为切入点，兼养心安神、益气健脾、和解枢机，用药以 “甘淡平补”为主，遣方用药与罗元恺教授之学术思想一脉相承。

Objective To explore the thoughts and medication rules of the contemporary inheritors of Lingnan LUO’ s Gynecology in differentiating and treating menopausal syndromes based on data mining technology. Methods The medical records of menopausal syndrome differentiated and treated by the contemporary inheritors of Lingnan LUO’ s Gynecology in clinic were collected. The Ancient and Modern Medical Records Cloud Platform （V2.3.5） was used to perform frequency statistics，association rule analysis，cluster analysis and complex network analysis of the data of medical records. Results A total of 191 medical records and 191 prescriptions were finally included，involving 160 kinds of Chinese medicinals. The statistics of four-examination information and syndrome types showed that the pathogenesis of menopausal syndrome was characterized by deficiency of the origin， which resulted in the dysfunction of healthy qi and the disturbance of the pivot，and then multiple viscera were involved；among the syndrome types，liver and kidney yin deficiency syndrome was the most common type. There were 26 high- frequency Chinese medicinals with the frequency being or over 40 times，and the top 5 Chinese medicinals were Lilii Bulbus，Codonopsis Radix，Corni Fructus，Paeoniae Radix Alba，and Rehmanniae Radix Praeparata. Most of the medicines were sweet in flavor and mild in nature，and had the meridian tropism of the liver，heart，kidney and spleen meridians. A total of 15 pairs of high-confidence drug combinations were obtained after association rule analysis. Cluster analysis of high-frequency Chinese medicinals yielded 5 core drug combinations. The complex network analysis revealed the core prescription which was composed of Rehmanniae Radix Praeparata，Corni Fructus，Cuscutae Semen，Lilii Bulbus，Ziziphi Spinosae Semen，Salviae Miltiorrhizae Radix et Rhizoma，and Margaritifera Concha. The association rule analysis showed that the drug pairs with high frequency of use were Ligustri Lucidi Fructus-Corni Fructus， Ligustri Lucidi Fructus-Salviae Miltiorrhizae Radix et Rhizoma. Conclusion For the treatment of menopausal syndrome， the contemporary inheritors of Lingnan LUO’s Gynecology take the therapy of nourishing liver and kidney as the key，and also adopt the therapies of nourishing the heart and calming the mind， benefiting qi and invigorating the spleen， and harmonizing the pivot. The medicines prescribed by the inheritors mostly are sweet-light and mild tonics， and their prescription and medication rules are consistent with Professor LUO Yuan-Kai s academic thoughts.

R271.11+ 5

国家自然科学基金项目 （编号：81804135）；全国名老中医药专家传承工作室建设项目 （国中医药人教函[2022]75号）；国家中医药 管理局全国中医学术流派传承工作室建设项目 （国中医药人教函[2019]62号）