观察通督醒神电针法联合复智胶囊治疗血管性痴呆的临床疗效。【方法】 将100例血管性痴呆患者随机分为观察 组和对照组，每组各50例。2组患者均给予常规治疗。对照组给予尼莫地平治疗，观察组在对照组治疗的基础上，给予通督 醒神电针法联合复智胶囊治疗。连续治疗4周。治疗1个月后，评价2组临床疗效，观察2组患者治疗前后执行性画钟作业 （CLOX）、Stroop测验的变化情况，以及简易精神状态检查量表（MMSE）、临床痴呆量表（CDR）评分的情况。比较2组患者治 疗前后精神功能评价量表（GAF）、简明精神病评定量表（BPRS）的变化情况。并观察 2 组患者治疗前后的超氧化物歧化酶 （SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）水平的变化情况。【结果】（1）治疗后，2 组患者的 CLOX、Stroop1、 Stroop2明显改善（P＜0.05），且观察组在改善 CLOX、Stroop1、Stroop2方面明显优于对照组，差异有统计学意义（P＜0.05）。 （2）治疗后，2组患者的 MMSE、CDR评分明显改善（P＜0.05），且观察组在改善 MMSE、CDR评分方面明显优于对照组，差 异有统计学意义（P＜0.05）。（3）治疗后，2组患者的GAF、BPRS评分明显改善（P＜0.05），且观察组在改善GAF、BPRS评分 方面明显优于对照组，差异有统计学意义（P＜0.05）。（4）治疗后，2组患者的SOD、MDA、GSH-Px水平明显改善（P＜0.05）， 且观察组在改善SOD、MDA、GSH-Px水平方面明显优于对照组，差异有统计学意义（P＜0.05）。【结论】 通督醒神电针法联合复 智胶囊治疗血管性痴呆，能明显改善患者的临床症状，提高患者SOD、GSH-Px水平，降低其MDA水平，疗效显著

To observe the clinical effect of Tongdu Xingshen electroacupuncture method combined with Fuzhi Capsules in the treatment of vascular dementia. Methods A total of 100 patients with vascular dementia were randomly divided into observation group and control group，50 cases in each group. Both groups were given routine treatment. The control group was treated with Nimodipine， and the observation group was treated with Tongdu Xingshen electroacupuncture method combined with Fuzhi Capsules on the basis of the treatment of the control group. The treatment was lasted for 4 continuous weeks. After one month of treatment，the clinical efficacy of the two groups was evaluated. The changes of executive clock drawing task （CLOX） and Stroop test，as well as the scores of Mini-Mental State Examination （MMSE） and Clinical Dementia Rating （CDR） were observed before and after treatment in the two groups. The changes of Mental Global Assessment Function （GAF） and brief psychiatric rating scale （BPRS） were compared before and after treatment between the two groups. The changes of superoxide dismutase （SOD），malondialdehyde （MDA） and glutathione peroxidase（GSH-Px） levels in the two groups before and after treatment were observed. Results （1） After treatment，the CLOX，Stroop1 and Stroop2 of the two groups were significantly improved （P＜0.05），and the improvement of CLOX，Stroop1 and Stroop2 in the observation group was significantly superior to that in the control group，the difference was statistically significant （P＜0.05）. （2） After treatment，the MMSE and CDR scores of the two groups were significantly improved（P＜0.05），and the improvement of MMSE and CDR scores in the observation group was significantly superior to that in the control group，the difference was statistically significant （P＜0.05）.（3） After treatment，the GAF and BPRS scores of the two groups were significantly improved（P＜0.05）， and the improvement of GAF and BPRS scores in the observation group was significantly superior to that in the control group，the difference was statistically significant （P＜0.05）.（4） After treatment， the levels of SOD， MDA and GSH-Px in the two groups were significantly improved （P＜0.05），and the improvement of SOD，MDA and GSH-Px in the observation group was significantly superior to that in the control group（P＜0.05）. Conclusion Tongdu Xingshen electroacupuncture method combined with Fuzhi Capsules in the treatment of vascular dementia can significantly improve the clinical symptoms of patients，improve the levels of SOD and GSH-Px，and reduce the level of MDA.

R246.9

河南省中医药科学研究专项课题资助项目（编号：20-21ZY1017）