观察疏肝调神针法治疗围绝经期轻中度抑郁障碍的临床疗效。【方法】 将66例围绝经期轻中度抑郁障碍患者随 机分为观察组和对照组，每组各33例。观察组给予疏肝调神针法治疗，对照组给予常规西药治疗，共治疗8周。治疗2个月 后，评价 2组临床疗效，观察 2组患者治疗前后汉密尔顿抑郁量表（HAMD-17）评分的变化情况，以及绝经期生存质量量表 （MENQOL）评分的情况。比较2组患者治疗前后血清黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）水平的变化情况。并 评价 2组的安全性及不良反应的发生情况。【结果】（1）研究过程中，观察组失访 3例，对照组失访 2例。最终观察组 30例、 对照组 31 例纳入疗效统计。（2）治疗后，2 组患者 HAMD-17 总分及各因子评分均明显改善（P＜0.05），且观察组在改善 HAMD-17总分及焦虑/躯体化因子、睡眠因子评分方面明显优于对照组，差异均有统计学意义（P＜0.05）。（3）治疗后，2组患 者 MENQOL总分及血管维度、生理维度、性生活维度评分均明显改善（P＜0.05），且观察组在改善 HAMD-17总分及血管维 度、生理维度评分方面明显优于对照组，差异均有统计学意义（P＜0.05）。（4）治疗后，2组患者LH、FSH及E2水平均明显改善（P＜0.05），且观察组在改善LH、FSH及E2水平方面明显优于对照组，差异有统计学意义（P＜0.05）。（5）观察组总有效率 为93.33%（28/30），对照组为74.19%（23/31）。观察组疗效优于对照组，差异有统计学意义（P＜0.05）。（6）观察组与对照组的 不良反应发生率比较，差异无统计学意义（P＞0.05）。【结论】 疏肝调神针法治疗围绝经期轻中度抑郁障碍，能够明显改善患 者的临床症状，提升患者的生存质量，调节性激素水平，疗效显著。

To observe the clinical efficacy of Shugan Tiaoshen Acupuncture in the treatment of mild-tomoderate perimenopausal depressive disorder（PDD）. Methods A total of 66 patients with mild-to-moderate PDD were randomly divided into the observation group and the control group， with 33 cases in each group. The observation group was treated with Shugan Tiaoshen Acupuncture， and the control group was treated with conventional western medicine for 8 weeks. After 2 months of treatment，the clinical efficacy of the two groups was evaluated，and the changes in Hamilton Depression Scale（HAMD-17） scores before and after treatment，as well as the scores of Menopausal Quality of Life Scale（MENQOL） were observed in the two groups. The changes in serum luteinising hormone （LH），follicle-stimulating hormone（FSH） and oestradiol （E2） levels were compared before and after treatment between the two groups，and the safety and the occurrence of adverse reactions in the two groups were evaluated. Results （1） During the study，3 cases in the observation group and 2 cases in the control group were lost to followup. Finally，30 cases in the observation group and 31 cases in the control group were included in the efficacy statistics.（2）After treatment，the total score of HAMD-17 and the scores of each factor in the two groups were significantly improved （P＜0.05），and the total score of HAMD-17 and the scores of anxiety/somatization factor and sleep factor in the observation group were significantly superior to those in the control group， the differences were statistically significant（P＜0.05）.（3）After treatment， the total score of MENQOL and the scores of vascular dimension， physiological dimension and sexual life dimension in the two groups were significantly improved（P＜0.05）， and the total score of HAMD-17 and the scores of vascular dimension and physiological dimension in the observation group were significantly superior to those in the control group，the differences were statistically significant （P＜0.05）.（4）After treatment，the levels of LH，FSH and E2 in the two groups were significantly improved （P＜0.05），and the improvement of LH，FSH and E2 levels in the observation group was significantly superior to that in the control group （P＜0.05）.（5） The total effective rate was 93.33%（28/30） in the observation group and 74.19% （23/31） in the control group. The curative effect of the observation group was superior to that of the control group，and the difference was statistically significant（P＞ 0.05）. Conclusion Shugan Tiaoshen Acupuncture in the treatment of mild-to-moderate PDD can significantly improve the clinical symptoms of patients， improve the quality of life of patients， regulate the level of sex hormones，and have a significant effect.

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国家自然科学基金资助项目（编号：81904293）；国家自然科学基金青年基金资助项目（编号：81704143）；广东省重点领域研发 计划专项资助项目（编号：2020B1111100007）；广东省中医药高质量发展传承创新提升工程专项（编号：粤财社[2022]102号）