慢性盆腔炎（CPID）是女性常见的慢性炎症性疾病，具有病程长、易复发的特点。当归芍药散出自《金匮要略》，为治 疗“妇人腹中诸疾痛”的常用方，现代常用于治疗CPID，并取得较好疗效。该文对近10年来当归芍药散治疗CPID的临床研 究和实验研究方面的文献进行总结分析，探讨当归芍药散治疗CPID的临床疗效及其作用机制。临床研究方面，应用当归芍 药散治疗CPID多使用原方加减用药，或单独使用，或联合抗生素及中医外治法；与单独应用西药相比，当归芍药散联合西 药可明显改善炎症指标及免疫功能指标、缓解疼痛等临床症状与体征，且未增加不良反应。实验研究方面，当归芍药散可 通过降低内皮细胞的黏附、调节细胞外基质的降解、改善炎性因子水平、下调核因子κB（NF-κB）通路相关蛋白表达等对 CPID发挥治疗作用。

Chronic pelvic inflammatory disease（CPID）is a common chronic inflammatory disease in women，and has a long course and is easy to relapse. Danggui Shaoyao Powder is from Jin Gui Yao Lve（Synopsis of the Golden Chamber），which was a commonly-used formula for the treatment of women’s abdominal pain in ancient medical records. It is now often used in the treatment of CPID and has achieved satisfactory therapeutic effect. The article summarizes and analyzes the achievements in the clinical research and experimental study of Danggui Shaoyao Powder in the treatment of CPID over the past 10 years，and invesigates the clinical efficacy of Danggui Shaoyao Powder in the treatment of CPID and its therapeutic mechanism. In the field of clinical studies，Danggui Shaoyao Powder for the treatment of CPID was used by modification， or alone， or in combination with antibiotics and Chinese medicine external treatment，and its combined use was effective on significantly improving the indicators of inflammatory response and immune function，alleviating the clinical signs and symptoms such as pain，and did not increase the incidence of adverse reactions compared with the application of western medicines alone. In the field of experimental studies， Danggui Shaoyao Powder played the therapeutic role in CPID by decreasing the adhesion of endothelial cells，regulating the degradation of extracellular matrix，improving the level of inflammatory factors，and down-regulating the expression of proteins related to the nuclear factor κB（NF-κB）pathway.

R271.933

欧阳惠卿全国名中医传承工作室项目[国中医药办人教函（2018）119号]