合成4种含氟的冰片酯，分析其结构及活性。【方法】以对甲苯磺酸为催化剂，通过含氟羧酸和冰片反应合成4 种含氟的冰片酯衍生物，采用1HNMR，13CNMR表征冰片酯的结构。通过AutoDock Vina 软件对4种含氟冰片酯与P-糖蛋白 进行分子对接。【结果】合成了4种含氟的冰片酯，分别是2-氯-4-三氟甲基苯甲酸冰片酯、2-氯-5-氟苯甲酸冰片酯、2- 氯-5-三氟甲基苯甲酸冰片酯、3-三氟甲基苯甲酸冰片酯。冰片酯的结构通过1HNMR、13CNMR证实。4种含氟冰片酯与P- 糖蛋白有较好的结合能力。【结论】合成了4种含氟的冰片酯化合物，含氟的冰片酯丰富了冰片衍生物的类型，对扩大冰片的 应用范围有一定参考价值。

Four fluorine- containing borneol ester were synthesized and analyzed for structure characterization and activity. Methods Four fluorine-containing borneol ester derivatives were synthesized by the reaction of fluorinated carboxylic acid and borneol by using p-toluenesulfonic acid as catalyst，and the structures of borneol esters were characterized by 1HNMR and 13CNMR. Molecular docking of the four fluorine-containing borneol ester with P-glycoprotein was carried out by Autodock Vina software. Results Four fluorine-containing borneol ester， bornyl 2-chloro- 4-trifluoromethyl benzoate， bornyl 2-chloro- 5-fluoro benzoate， bornyl 2- chloro-5-trifluoromethyl benzoate， bornyl 3-trifluoromethyl benzoate， were synthesized. The structures of the borneol ester were confirmed by 1HNMR and 13CNMR. 4 fluorine-containing borneol ester had good binding ability with P-glycoprotein. Conclusion Four borneol ester compounds were synthesized，and the borneol ester enriched the types of borneol derivatives，which is of reference value for expanding the application range of borneol.

R284.3