该研究对山仙颗粒抑制肝癌、肺癌、肉瘤、黑色素瘤等肿瘤的作用机制进行了综述，以期为山仙颗粒治疗恶性肿瘤 提供依据。山仙颗粒是陕西中医药大学肿瘤学团队在中医辨证论治理论的基础上结合数十年的临床经验以及现代药理研究 成果而研制的抗恶性肿瘤的纯中药制剂，主要由山楂、仙鹤草、西洋参、莪术、龟甲、鳖甲、延胡索、猪苓等组成，具有 益气养阴、扶正培本及活血化瘀、消肿抗癌的功效，该制剂的药物组成体现了扶正不敛邪、祛邪不伤正的组方原则。山仙 颗粒能有效抑制肝癌、肺癌、肉瘤、黑色素瘤等肿瘤的体内外生长与转移，减轻肿瘤患者临床症状，改善预后。其疗效 机制与增强机体免疫功能、抑制肿瘤细胞增殖、促进肿瘤细胞发生凋亡、抑制肿瘤细胞侵袭与转移、抑制肿瘤血管形成等 有关。

In this article， the mechanism of Shanxian Granule in inhibiting liver cancer， lung cancer， sarcoma，melanoma and other tumors was reviewed，with a view to providing a theoretical basis for the clinical research of Shanxian Granules in the treatment of malignant tumors. Shanxian Granule are the pure Chinese medicine preparation for counteracting malignant tumor developed by the Oncology Research Team of Shaanxi University of Chinese Medicine on the basis of the theory of traditional Chinese medicine syndrome differentiation and treatment combined with decades of clinical experience as well as the achievements of modern pharmacological research. Shanxian Granule are mainly composed of Crataegi Fructus，Agrimoniae Herba，Panacis Quinquefolii Radix， Curcumae Rhizoma， Testudinis Carapax et Plastrum， Trionycis Carapax， Corydalis Rhizoma， and Polyporus， and have the actions of benefiting qi and nourishing yin， supporting healthy-qi and cultivating the essence， activating blood and removing stasis， and eliminating swelling and counteracting cancer. The compatibility of Shanxian Granule embodies the principle of supporting healthy- qi but avoiding maintaining pathogens， and eliminating pathogens but avoiding injuring healthy-qi. The granules can effectively inhibit the growth and metastasis of liver cancer， lung cancer， sarcoma， melanoma and other tumors both in vivo and in vitro，alleviate the clinical symptoms of tumor patients，and improve their prognosis. The anti-tumor mechanism of Shanxian Granules is related to the enhancement of body immune function， inhibition of tumor cell proliferation，enhancement of tumor cell apoptosis，inhibition of tumor cell invasion and metastasis as well as the tumor angiogenesis.

R285.5

国家自然科学基金项目（编号：82003806）