阿尔茨海默病（AD）是多种原因导致的一种神经退行性疾病，该病以记忆障碍为特征。AD的有效治疗一直存在严重的 阻碍。针刺作为中医学的组成部分，在AD的治疗中发挥着重要的作用。针刺可保护神经元免受退化并促进神经退行性疾病 （如AD）的轴突再生。针刺对AD的作用机制包括以下几个方面：调节Aβ代谢、tau磷酸化、胆碱能神经递质、神经炎症、突 触和神经元功能、自噬、脑葡萄糖代谢、肠道菌群，抑制神经细胞凋亡，进而改善认知。

Alzheimer’s disease（AD） is a multi- cause neurodegenerative disease characterized by memory impairment. There have been serious obstacles to the effective treatment of AD. Acupuncture，as a component of traditional Chinese medicine， plays an important role in the treatment of AD. Acupuncture has been shown to protect neurons from degeneration and promotes axonal regeneration in neurodegenerative diseases such as AD. According to existing studies，the mechanisms of acupuncture on AD include the following aspects：modulation of Aβ metabolism，tau phosphorylation，cholinergic neurotransmitters，neuroinflammation，synaptic and neuronal function，autophagy，brain glucose metabolism，intestinal flora，and inhibition of nerve cell apoptosis，which in turn improves cognition.

R246.9

国家重点研发计划资助项目（编号：2022YFB4703104）