该文通过对近年来莲心碱针对高血压发病机制及其靶器官损伤的相关药理作用的研究进展进行综述，以期为高血压 的新药研发提供思路。莲子心具有清心除烦、安神助眠、交通心肾等功效，莲心碱是从莲子心中提取的双苄基异喹啉类生 物碱之一。目前大量体内外实验证明，莲心碱能够抑制炎症反应与氧化应激反应，松弛平滑肌，降低不同高血压动物模型 的血压，同时也可保护心、肾、脑、血管等多个靶器官的损害；并且莲心碱冻干粉已得到成功研发。研究成果提示莲心碱 具有进一步开发为治疗高血压新药的潜力。

This article reviewed the progress on the research of pharmacological actions of liensinine on the pathogenesis of hypertension and the hypertention-associated target organ damage in recent years，aiming to provide insights for the development of novel antihypertensive drugs. Nelumbinis Plumula（lotus seed plumule）is traditionally known for its actions of clearing heart and relieving vexation，calming spirit and improving sleep，and coordinating between heart and kidney. Liensinine is one of the bibenzylisoquinoline alkaloids extracted from Nelumbinis Plumula. Recently，a large amount of in vivo and in vitro studies have demonstrated that liensinine has the effects on suppressing inflammatory responses and oxidative stress，relaxing smooth muscle，lowering blood pressure in various hypertensive animal models，and concurrently protecting against damage to multiple target organs，i.e.，the heart，kidneys，brain，and blood vessels. Furthermore，lyophilized powder of liensinine has been successfully developed. These findings suggest that liensinine possesses considerable potential for further development as a novel therapeutic agent for hypertension.

R285.6

国家自然科学基金青年基金项目（编号：82004126）；福建省科技厅科技联合基金项目（编号：2025Y9556）