2 型糖尿病（T2DM）可归属中医学的“消渴”范畴，但现今临床所见的T2DM 以肥胖型患者居多，患者可见寒热错杂 的证候。朱章志教授认为，针对此类寒热错杂之T2DM 患者，可从太阴辨治，认为其病机属太阴开机不利，阳虚失运。治疗 以“温运太阴脾”“清宣太阴肺”“寒温并用”为大法，以“广义寒热错杂方”为主方，该方在半夏泻心汤的基础上合用了 理中丸、麻杏甘石汤等多个经方，使脾阳健运，肺气宣肃，太阴得开，太阴开则气机升降有序，阳气得以有效潜藏。

Type 2 diabetes mellitus（T2DM）can be categorized under the scope of Xiaoke in traditional Chinese medicine. However，most T2DM cases currently encountered in clinical practice are of the obese patients， presenting with symptoms of mixture of cold and heat. For such T2DM patients with mixture of cold and heat， Professor Zhu Zhangzhi posits that their treatment can be approached from the perspective of taiyin. He believes that the pathogenesis lies in impaired opening function of taiyin and yang deficiency with failure of transportation. The therapeutic strategy is centered on the principles of warming and activating the taiyin spleen，clearing and ventilating the taiyin lung，and simultaneous use of cold and warm medicinals. The Generalized Formula for Mixture of Cold and Heat is used as the main prescription. The formula is modified from Banxia Xiexin Decoction， incorporating multiple classical formulas such as Lizhong Pills and Ma Xing Gan Shi Decoction，aiming to activate the spleen yang，ventilate and descend the lung qi，and facilitate the opening of taiyin. Once taiyin is opened， the ascending and descending of qi movement become orderly，and then yang qi can be effectively subsided and stored.

R259.871

国家自然科学基金项目（编号：82174284）