【目的】通过数据挖掘方法总结当代岭南地区名中医治疗糖尿病的组方用药规律。【方法】检索中国知网（CNKI）、万方 （Wanfang）和维普（VIP）数据库中当代岭南名中医治疗糖尿病的文献，并查阅当代岭南名中医的经验集、医案集，筛选岭南 名中医治疗糖尿病的相关医案。将医案中治疗糖尿病的中药处方资料录入Excel建立数据库，对中药的性味归经、分类和中 医证型等进行频数统计，并采用IBM SPSS Modeler 18.0和SPSS Statistics 26.0进行关联规则分析和聚类分析。【结果】共纳入包 括邓铁涛、刘仕昌、熊曼琪、李赛美、朱章志、刘敏、范冠杰等24位当代岭南地区名中医辨治糖尿病的医案资料，筛选 得到62篇医案， 101首处方，涉及210味中药。出现频次≥ 15次的常用中药有炙甘草、黄芪、柴胡、葛根、茯苓、白术、 党参、黄芩等29味，中药功效分类的类别以补虚药、清热药、祛风湿药为主。证型主要为脾肾两虚证、肝郁脾虚证，并涉 及气虚、阴虚、阳虚、寒湿、痰湿、湿热等证素。关联规则分析得到2 ~ 4味的核心药物组合28个，聚类分析得到5个新处 方组合，主要为小柴胡汤、附子理中汤、玉泉丸合增液汤、左归丸等经典方剂的化裁方。【结论】当代岭南地区名中医治疗 糖尿病主要以健脾温肾、疏肝利湿化浊为法，具有较鲜明的地域特色，可为岭南地区辨治糖尿病提供参考。

Objective To summarize the prescription and medication rules for the treatment of diabetes mellitus by contemporary Lingnan famous Chinese medical practitioners through data mining analysis. Methods The literature on treating diabetes mellitus by contemporary Lingnan famous Chinese medical practitioners were retrieved from the databases of CNKI， Wanfang and VIP， and the collections of clinical experience and medical cases of contemporary Lingnan famous practitioners were also reviewed to screen the relevant medical records of diabetes mellitus treated by Lingnan famous practitioners. The information of Chinese medicine prescriptions for diabetes mellitus in the medical records was input to Excel to establish a database，and then the frequency analysis was performed in terms of the nature，flavors and meridian tropism，therapeutic-action classification of the Chinese herbal medicines and traditional Chinese medicine（TCM）syndrome types. Moreover，the association rule analysis and cluster analysis were carried out using IBM SPSS Modeler 18.0 and SPSS Statistics 26.0. Results A total of 62 medical records of diabetes mellitus treated by the 24 contemporary Lingnan famous Chinese medical practitioners such as DENG Tie-Tao，LIU Shi-Chang，XIONG Man-Qi，LI Sai-Mei，ZHU Zhang-Zhi，LIU Min，and FAN Guan-Ji were screened out for the analysis. And a total of 101 prescriptions involving 210 Chinese herbal medicines were included. There were 29 commonly-used Chinese medicines with a frequency being or more than 15 times，and they were Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，Astragali Radix，Bupleuri Radix，Puerariae Lobatae Radix，Poria，Atractylodis Macrocephalae Rhizoma，Codonopsis Radix，Scutellariae Radix，etc. According to the therapeutic action，the Chinese medicines were mainly classified into the categories of drugs for supplementing the deficiency， drugs for clearing heat， and drugs for dispelling wind-damp. The primary syndrome types were syndrome of deficiency of both spleen and kidney and syndrome of liver stagnation and spleen deficiency，and the syndromes were usually complicated with the syndrome elements of qi deficiency， yin deficiency， yang deficiency， cold-damp， phlegm-damp， and damp-heat. The association rule analysis yielded 28 core drug combinations consisting of 2-4 herbs， and the cluster analysis yielded 5 new candidate prescriptions， which were mainly derived from the modification of classical formulas such as Xiao Chaihu Decoction，Fuzi Lizhong Decoction，Yuquan Pills plus Zengye Decoction，and Zuogui Pills. Conclusion For the treatment of diabetes mellitus， contemporary Lingnan famous Chinese medical practitioners primarily adopt the methods of invigorating spleen and warming kidney， and soothing liver， draining dampness and resolving turbidity，which has more distinctive regional characteristics of Lingnan and can provide a reference for syndrome differentiation and treatment of diabetes mellitus in the Lingnan area.

R255.4

国家自然科学基金项目（编号：8217150016）