【目的】采用数据挖掘技术挖掘国医大师禤国维教授治疗儿童特应性皮炎的组方用药规律。【方法】收集禤国维教授门 诊治疗儿童特应性皮炎的有效病例的病案资料，采用频数统计、关联规则分析、聚类分析等方法对录入的病案数据进行统 计分析。【结果】共收录处方242首，涉及中药101味。常用药物为23味，高频药物（频数＞100次）共16味，分别为甘草、防 风、北沙参、紫苏叶、麦冬、徐长卿、布渣叶、白鲜皮、玄参、薏苡仁、蝉蜕、百合、生地黄、地肤子、茯神、芡实。药 物的性味归经分析显示，药物大多偏甘寒，主要归脾、胃、肝经。关联规则分析得到常用药物组合24个，关联规则20条。 聚类分析得到2个核心药物组合。【结论】禤国维治疗儿童特应性皮炎以“清、补、和”三法为主，“扶正御邪，平调阴阳” 的用药原则贯穿治疗始终。

Objective Data mining technology was used to mine the medication rules of the prescriptions used in the treatment of pediatric atopic dermatitis by Chinese medical master XUAN Guo-Wei. Methods The medical records of effective cases of pediatric atopic dermatitis treated by Professor XUAN Guo-Wei at outpatient clinic were collected，and then the medical data were statistically analyzed using frequency statistics，association rule analysis and cluster analysis. Results A total of 242 prescriptions were included， involving 101 Chinese medicinals. There were 23 commonly-used herbs，and the 16 high-frequency herbs（frequency＞100 times）were Glycyrrhizae Radix et Rhizoma， Saposhnikoviae Radix， Glehniae Radix， Perillae Folium， Ophiopogonis Radix， Cynanchi Paniculati Radix et Rhizoma， Microctis Folium， Dictamni Cortex， Scrophulariae Radix， Coicis Semen，Cicadae Periostracum，Lilii Bulbus，Rehmanniae Radix， Kochiae Fructus，Sclerotium Poriae Pararadicis， and Euryales Semen. The analysis of the medicinal properties showed that most of the herbs were sweet and cold，and mainly had the meridian tropism of the spleen，stomach and liver meridians. The association rule analysis yielded 24 commonly-used drug combinations and 20 association rules. Cluster analysis yielded 广州中医药大学学报 Journal of Guangzhou University of Traditional Chinese Medicine 2024年3月第41卷第3期 752 March 2024，Vol. 41，No. 3 2 core drug combinations. Conclusion For the treatment of pediatric atopic dermatitis，Professor XUAN Guo-Wei focuses on the clearing，supplementing and harmonizing therapies，and the medication principle of“supporting the healthy-qi to eliminate the pathogen，and balancing the yin and yang”is applied throughout the treatment.

R275.9

广东省重点领域研发计划项目（编号：2020B1111100010）；国家中医药管理局中医学术流派传承工作室建设项目-岭南皮肤病流派 传承工作室（编号：LP0119045）；广州中医药大学“双一流”与高水平大学学科协同创新团队（编号：2021XK08）